Details:
This article will provide a workaround to enable or disable Cache Mode on Outlook 2010 when the check box is gray out.
Solution:
To Enable Cache Mode on:

1. Open REGEDIT
2. navigate to the following registry: HKEY_CURRENT_USER\Software\Policies\Microsoft\Office\14.0\outlook\cached mode
3. Modify Value on dword “Enable”=dword to 1

4. Close Registry Editor

5. Restart Outlook

 
To Disable Cache Mode on:

1. Open REGEDIT
2. navigate to the following registry: HKEY_CURRENT_USER\Software\Policies\Microsoft\Office\14.0\outlook\cached mode
3. Modify Value on dword “Enable”=dword to 0

4. Close Registry Editor

5. Restart Outlook

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